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Who was studied 61,588 European ancestry cases, 330,161 European ancestry controls, 899 Japanese ancestry cases, 3,396 Japanese ancestry controls.
The effect
Each copy of the A allele carried 0.95 times the odds of Knee osteoarthritis (95% confidence interval 0.9357455-0.962531718); p = 3 × 10−13.
How common The A allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 16, band 16q22.1 — in an intron of WWP2.
What each result means
A/ATwo copies of the version the research linked to Knee osteoarthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Knee osteoarthritis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Knee osteoarthritis. This is the starting point the study compared everyone against.
rs34195470 is a single position in the genome, in or near the WWP2 gene. Published research associates it with knee osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34195470 linked to?
On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs34195470 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34195470 come from?
GWAS Catalog, Cell 2021, PMID:34450027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 11227Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others7Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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