Standard

Heart failure

SYNPO2L · rs34163229

Where this position leads

Condition: Heart Failure

rs34163229 Condition: Heart Failure Heart Failure Condition rs34163229 rs34163229 SYNPO2L

What the study found

Who was studied 90,653 European ancestry cases, 1,188,957 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.056 lower (95% confidence interval 0.04-0.072); p = 7 × 10−13.

Where it sits Chromosome 10, band 10q22.2 — a missense change in SYNPO2L.

What each result means

G/G No copy of the version the research linked to Heart failure. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Heart failure. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Heart failure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs34163229

What is rs34163229?

rs34163229 is a single position in the genome, in or near the SYNPO2L gene. Published research associates it with heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34163229 linked to?

On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.

Does having rs34163229 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34163229 come from?

GWAS Catalog, Nature communications 2023, PMID:37429843. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Heart failure (rs34163229). MyGeneLog™. https://www.mygenelog.com/variants/rs34163229

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