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Headache

near GPR149 · rs34097149

Where this position leads

Condition: Headache

rs34097149 Condition: Headache Headache Condition rs34097149 rs34097149 near GPR149

What the study found

Who was studied 74,461 British ancestry cases, 149,321 British ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0297 lower (95% confidence interval 0.021-0.039); p = 1 × 10−10.

Where it sits Chromosome 3, band 3q25.2 — between genes, 106.3 kb from SYPL1P1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Headache compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Headache.
T/T Published research associates this genotype with typical/baseline likelihood of Headache — no copies of the reported risk allele.
Source
A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773)
Meng W, Adams MJ, Hebert HL, Deary IJ, McIntosh AM, Smith BH
EBioMedicine · 2018 · PMID 29397368 · open access

Questions about rs34097149

What is rs34097149?

rs34097149 is a single position in the genome, in or near the near GPR149 gene. Published research associates it with headache. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34097149 linked to?

On MyGeneLog this position is linked to Headache. The research behind each link, and its sources, are set out on that condition page.

Does having rs34097149 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34097149 come from?

GWAS Catalog, EBioMedicine 2018, PMID:29397368. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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