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Sensitive

Systemic lupus erythematosus

AFF1 · rs340630

Where this position leads

Condition: Systemic Lupus Erythematosus

rs340630 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs340630 rs340630 AFF1

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic lupus erythematosus compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic lupus erythematosus.
G/G Published research associates this genotype with typical/baseline likelihood of Systemic lupus erythematosus — no copies of the reported risk allele.
Source
A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese
Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Horita T, Atsumi T, Ishii T, Okamoto A, Fujio K
and 32 more — show all
Hirakata M, Amano H, Kondo Y, Ito S, Takada K, Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed OW, Matsuda K, Terao C, Ohmura K, Myouzen K, Hosono N, Tsunoda T, Nishimoto N, Mimori T, Matsuda F, Tanaka Y, Sumida T, Yamanaka H, Takasaki Y, Koike T, Horiuchi T, Hayashi K, Kubo M, Kamatani N, Yamada R, Nakamura Y, Yamamoto K
PLoS genetics · 2012 · PMID 22291604 · open access

Questions about rs340630

What is rs340630?

rs340630 is a single position in the genome, in or near the AFF1 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs340630 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs340630 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs340630 come from?

GWAS Catalog, PLoS Genet 2012, PMID:22291604. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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