TNFRSF1B · rs3397
Where this position leads
Condition: Celiac Disease
What the study found
Who was studied 47,745 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.0408 lower (95% confidence interval 0.028-0.053); p = 9 × 10−12.
How common The T allele had a frequency of about 64% in the people studied.
Where it sits Chromosome 1, band 1p36.22 — in the 3′ untranslated region of TNFRSF1B.
What ClinVar records
Classification
Uncertain significance for Susceptibility to severe coronavirus disease (COVID-19), Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF, TNFR, and/or TNFR3, Associated with severe COVID-19 disease; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2023-07-01.
ClinVar record 1048803 NM_001066.3(TNFRSF1B):c.*215C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs3397 is a single position in the genome, in or near the TNFRSF1B gene. Published research associates it with tnfrsf1b protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
TNFRSF1B protein levels (rs3397). MyGeneLog™. https://www.mygenelog.com/variants/rs3397