Standard

Malaria, resistance to

HBB · rs33930165

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

3 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 2 of 4 stars. Its strongest genetic-study result is p = 10⁻⁴², with 32 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic/Likely pathogenic for Malaria, resistance to, HEMOGLOBIN C, Hb SS disease, beta Thalassemia, Heinz body anemia and 9 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 37 submitters), last evaluated 2026-08-03. ClinVar record 15126 NM_000518.4(HBB):c.19G>A (p.Glu7Lys)

Classification Uncertain significance for HEMOGLOBIN MACHIDA; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2024-11-06. ClinVar record 15243 NM_000518.4(HBB):c.19G>C (p.Glu7Gln)

Classification Pathogenic for beta Thalassemia; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2019-11-25. ClinVar record 869230 NM_000518.5(HBB):c.19G>T (p.Glu7Ter)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version ClinVar lists as disease-causing or likely disease-causing for Malaria, resistance to. This is the usual result. (ClinVar VCV000015126, criteria provided, multiple submitters, no conflicts)

C/T One copy of the version ClinVar lists as disease-causing or likely disease-causing for Malaria, resistance to. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV000015126, criteria provided, multiple submitters, no conflicts)

T/T Two copies of the version ClinVar lists as disease-causing or likely disease-causing for Malaria, resistance to. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000015126, criteria provided, multiple submitters, no conflicts)

Source: ClinVar VCV000015126, criteria provided, multiple submitters, no conflicts

Quoting this page

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Malaria, resistance to (rs33930165). MyGeneLog™. https://www.mygenelog.com/variants/rs33930165

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