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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 247,107 European ancestry individuals; replicated in 63,326 European ancestry individuals, 33,171 South Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0179 lower (95% confidence interval 0.013-0.023); p = 2 × 10−11.
How common The C allele had a frequency of about 66% in the people studied.
Where it sits Chromosome 17, band 17q24.3 — between genes, 28.8 kb from MAP2K6.
What each result means
C/CTwo copies of the version the research linked to Thyroid stimulating hormone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Thyroid stimulating hormone levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Thyroid stimulating hormone levels. This is the starting point the study compared everyone against.
Nature communications · 2023 · PMID 37872160 · open access
Questions about rs333933
What is rs333933?
rs333933 is a single position in the genome, in or near the near MAP2K6 gene. Published research associates it with thyroid stimulating hormone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs333933 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs333933 come from?
GWAS Catalog, Nature communications 2023, PMID:37872160. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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