NFIA · rs332827
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied up to 53,293 European ancestry Attention-deficit/hyperactivity disorder individuals, up to 164,684 European ancestry problematic alcohol use individuals, up to 186,875 European ancestry lifetime cannabis use individuals, up to 357,187 European ancestry individuals measuring reverse-coded age at first sexual intercourse, up to 336,121 European ancestry individuals measuring number of sexual partners, up to 426,379 European ancestry individuals measuring general risk tolerance, up to 1,251,809 European ancestry individuals measuring lifetime smoking initiation.
The effect Each copy of the G allele shifted the measure 0.01 higher (95% confidence interval 0.008-0.012); p = 3 × 10−17.
How common The G allele had a frequency of about 54% in the people studied.
Where it sits Chromosome 1, band 1p31.3 — in an intron of NFIA.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-07-21.
ClinVar record 1295336 NM_001134673.4(NFIA):c.560-32G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs332827 is a single position in the genome, in or near the NFIA gene. Published research associates it with externalizing behaviour (multivariate analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature neuroscience 2021, PMID:34446935. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Externalizing behaviour (multivariate analysis) (rs332827). MyGeneLog™. https://www.mygenelog.com/variants/rs332827