Sensitive

Bipolar disorder lithium response (categorical) or schizophrenia

MEF2C · rs324899

Where this position leads

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Bipolar disorder lithium response (categorical) or schizophrenia compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Bipolar disorder lithium response (categorical) or schizophrenia.

G/G Published research associates this genotype with typical/baseline likelihood of Bipolar disorder lithium response (categorical) or schizophrenia — no copies of the reported risk allele.

Source

Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study

Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N

and 100 more — show all

Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Étain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Volkert J, Witt S, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT

International Consortium on Lithium Genetics (ConLi+Gen)

JAMA psychiatry · 2018 · PMID 29121268

Questions about rs324899

What is rs324899?

rs324899 is a single position in the genome, in or near the MEF2C gene. Published research associates it with bipolar disorder lithium response (categorical) or schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs324899 linked to?

On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs324899 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs324899 come from?

GWAS Catalog, JAMA Psychiatry 2017, PMID:29121268. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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