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Peripheral artery disease

LPL · rs322

Where this position leads

Condition: Peripheral Artery Disease

rs322 Condition: Peripheral Artery Disease Peripheral Artery Disease Condition rs322 rs322 LPL

What the study found

Who was studied 12,086 European ancestry cases, 449,548 European ancestry controls; replicated in 31,307 cases, 211,753 controls, 3,164 East Asian ancestry cases, 20,134 East Asian ancestry controls.

The effect Each copy of the A allele carried 1.06 times the odds of Peripheral artery disease (95% confidence interval 1.04-1.07); p = 2 × 10−9.

How common The A allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 8, band 8p21.3 — in an intron of LPL.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Peripheral artery disease compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Peripheral artery disease.
C/C Published research associates this genotype with typical/baseline likelihood of Peripheral artery disease — no copies of the reported risk allele.
Source
Genome-Wide Association Study of Peripheral Artery Disease
van Zuydam NR, Stiby A, Abdalla M, Austin E, Dahlström EH, Dahlström EH, McLachlan S, Vlachopoulou E, Ahlqvist E, Di Liao C, Sandholm N, Forsblom C
and 21 more — show all
Mahajan A, Robertson NR, Rayner NW, Lindholm E, Sinisalo J, Perola M, Kallio M, Weiss E, Price J, Paterson A, Klein B, Salomaa V, Palmer CNA, Groop PH, Groop L, McCarthy MI, de Andrade M, Morris AP, Hopewell JC, Colhoun HM, Kullo IJ
GoLEAD Consortium, SUMMIT Consortium†
Circulation. Genomic and precision medicine · 2021 · PMID 34601942 · open access

Questions about rs322

What is rs322?

rs322 is a single position in the genome, in or near the LPL gene. Published research associates it with peripheral artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs322 linked to?

On MyGeneLog this position is linked to Peripheral Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs322 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs322 come from?

GWAS Catalog, Circulation. Genomic and precision medicine 2021, PMID:34601942. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Peripheral artery disease (rs322). MyGeneLog™. https://www.mygenelog.com/variants/rs322

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