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Intraocular pressure

ANKH · rs31916

Where this position leads

Condition: Intraocular Pressure

rs31916 Condition: Intraocular Pressure Intraocular Pressure Condition rs31916 rs31916 ANKH

What the study found

Who was studied 101,939 European ancestry cases.

The effect Each copy of the A allele shifted the measure 0.1 higher (95% confidence interval 0.061-0.139); p = 4 × 10−10.

Where it sits Chromosome 5, band 5p15.2 — in an intron of ANKH.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Intraocular pressure compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Intraocular pressure.
G/G Published research associates this genotype with typical/baseline likelihood of Intraocular pressure — no copies of the reported risk allele.
Source
Association of Myopia and Intraocular Pressure With Retinal Detachment in European Descent Participants of the UK Biobank Cohort: A Mendelian Randomization Study
Han X, Ong JS, An J, Craig JE, Gharahkhani P, Hewitt AW, MacGregor S
JAMA ophthalmology · 2020 · PMID 32352494

Questions about rs31916

What is rs31916?

rs31916 is a single position in the genome, in or near the ANKH gene. Published research associates it with intraocular pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs31916 linked to?

On MyGeneLog this position is linked to Intraocular Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs31916 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs31916 come from?

GWAS Catalog, JAMA ophthalmology 2020, PMID:32352494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Intraocular pressure (rs31916). MyGeneLog™. https://www.mygenelog.com/variants/rs31916

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