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Sensitive

Tumor necrosis factor ligand superfamily member 8 levels

DELEC1 · rs3181354

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−28, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 3,506 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.284 lower (95% confidence interval 0.24-0.33); p = 4 × 10−29.

How common The G allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 9, band 9q33.1 — in a regulatory region of DELEC1.

How common each version is

AG
Korean KRGDB
A 97.7% · G 2.3%
Korean Korea4K
A 97.8% · G 2.2%
Korean Korea1K
A 98.4% · G 1.6%
Japanese ToMMo
A 98.6% · G 1.4%
World gnomAD
A 77.9% · G 22.1%
World 1000 Genomes
A 82.1% · G 17.9%
World TOPMed
A 78.4% · G 21.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Tumor necrosis factor ligand superfamily member 8 levels. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Tumor necrosis factor ligand superfamily member 8 levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Tumor necrosis factor ligand superfamily member 8 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease
Western D, Timsina J, Wang L, Wang C, Yang C, Phillips B, Wang Y, Liu M, Ali M, Beric A, Gorijala P, Kohlfeld P
and 28 more — show all
Budde J, Levey AI, Morris JC, Perrin RJ, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson EN, Le Guen Y, Reus LM, Tijms B, Visser PJ, van der Lee SJ, Pijnenburg YAL, Teunissen CE, Del Campo Milan M, Alvarez I, Aguilar M, Greicius MD, Pastor P, Pulford DJ, Ibanez L, Wyss-Coray T, Sung YJ, Cruchaga C
Dominantly Inherited Alzheimer Network (DIAN) · Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Nature genetics · 2024 · PMID 39528825

Quoting this page

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Tumor necrosis factor ligand superfamily member 8 levels (rs3181354). MyGeneLog™. https://www.mygenelog.com/variants/rs3181354

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