Sensitive

Hepatocellular carcinoma

HLA-DPA1 · rs3179778

Where this position leads

Condition: HBV-Related Hepatocellular Carcinoma

rs3179778 Condition: HBV-Related Hepatocellular Carcinoma HBV-Related Hepatocellular Carcinoma Condition rs3179778 rs3179778 HLA-DPA1

What the study found

Who was studied 2,792 East Asian ancestry cases, 235,223 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.208 higher (95% confidence interval 0.15-0.26); p = 1 × 10−13.

Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DPA1.

What each result means

A/A Two copies of the version the research linked to Hepatocellular carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Hepatocellular carcinoma. That is a smaller link than two copies.
G/G No copy of the version the research linked to Hepatocellular carcinoma. This is the starting point the study compared everyone against.
Source

Questions about rs3179778

What is rs3179778?

rs3179778 is a single position in the genome, in or near the HLA-DPA1 gene. Published research associates it with hepatocellular carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3179778 linked to?

On MyGeneLog this position is linked to HBV-Related Hepatocellular Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs3179778 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3179778 come from?

GWAS Catalog, JHEP reports : innovation in hepatology 2025, PMID:40823170. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hepatocellular carcinoma (rs3179778). MyGeneLog™. https://www.mygenelog.com/variants/rs3179778

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