Gene Knowledge Graph
UTC

Links from this page to related variants, conditions, drugs and topics are not included for automated readers. Those connections are the Gene Knowledge Graph and are licensed as data: https://www.mygenelog.com/license

Standard

N1-methyladenosine levels

SLC22A2 · rs316021

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−18, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 14,296 European ancestry individuals; replicated in 5,698 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.103 lower (95% confidence interval 0.08-0.126); p = 9 × 10−19.

How common The T allele had a frequency of about 76% in the people studied.

Where it sits Chromosome 6, band 6q25.3 — in an intron of SLC22A2.

How common each version is

CT
Korean KRGDB
C 19.7% · T 80.3%
Korean Korea4K
C 19.7% · T 80.3%
Korean Korea1K
C 19.3% · T 80.7%
Japanese ToMMo
C 19.3% · T 80.7%
Vietnamese
C 23.3% · T 76.7%
World gnomAD
C 29.9% · T 70.1%
World 1000 Genomes
C 31.0% · T 69.0%
World TOPMed
C 31.0% · T 69.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to N1-methyladenosine levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to N1-methyladenosine levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to N1-methyladenosine levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Rare and common genetic determinants of metabolic individuality and their effects on human health
Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF, Wittemans LBL, Bomba L, Menni C, Zierer J
and 24 more — show all
Rossi N, Sheridan PA, Watkins NA, Mangino M, Hysi PG, Di Angelantonio E, Falchi M, Spector TD, Soranzo N, Michelotti GA, Arlt W, Lotta LA, Denaxas S, Hemingway H, Gamazon ER, Howson JMM, Wood AM, Danesh J, Wareham NJ, Kastenmüller G, Fauman EB, Suhre K, Butterworth AS, Langenberg C
Nature medicine · 2022 · PMID 36357675 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

N1-methyladenosine levels (rs316021). MyGeneLog™. https://www.mygenelog.com/variants/rs316021

← See all variants