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Who was studied 11,361 European ancestry female cases, 18,119 European ancestry female controls, 20,206 European ancestry male cases, 19,375 European ancestry male controls, 686 East Asian ancestry female cases, 1,907 East Asian ancestry female controls, 1,150 East Asian ancestry male cases, 1,476 East Asian ancestry male controls.
The effect
Each copy of the A allele shifted the measure 0.116 higher (95% confidence interval 0.079-0.152); p = 4 × 10−10.
How common The A allele had a frequency of about 75% in the people studied.
Where it sits Chromosome 15, band 15q22.1 — in an intron of SLTM.
What each result means
A/ATwo copies of the version the research linked to Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Schizophrenia. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Schizophrenia. This is the starting point the study compared everyone against.
rs3145 is a single position in the genome, in or near the SLTM gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3145 linked to?
On MyGeneLog this position is linked to Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk). The research behind each link, and its sources, are set out on that condition page.
Does having rs3145 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3145 come from?
GWAS Catalog, Biological psychiatry 2022, PMID:34099189. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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