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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,557 European ancestry cases, 456,942 European ancestry controls, 994 East Asian ancestry cases, 172,656 East Asian ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.329 higher (95% confidence interval 0.24-0.42); p = 1 × 10−13.
Where it sits Chromosome 6, band 6p22.1 — in an intron of TRIM27.
What each result means
C/CTwo copies of the version the research linked to Hyperthyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Hyperthyroidism. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Hyperthyroidism. This is the starting point the study compared everyone against.
rs3135293 is a single position in the genome, in or near the TRIM27 gene. Published research associates it with hyperthyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs3135293 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3135293 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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