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KDR protein levels

near HLA-DQB1 · rs3135000

Where this position leads

Condition: Celiac Disease

rs3135000 Condition: Celiac Disease Celiac Disease Condition rs3135000 rs3135000 near HLA-DQB1

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−14, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0373 lower (95% confidence interval 0.027-0.047); p = 9 × 10−15.

How common The A allele had a frequency of about 46% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 0.6 kb from HLA-DQB1.

What each result means

A/A Two copies of the version the research linked to KDR protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to KDR protein levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to KDR protein levels. This is the starting point the study compared everyone against.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs3135000

What is rs3135000?

rs3135000 is a single position in the genome, in or near the near HLA-DQB1 gene. Published research associates it with kdr protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3135000 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs3135000 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3135000 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

KDR protein levels (rs3135000). MyGeneLog™. https://www.mygenelog.com/variants/rs3135000

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