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Non-HDL cholesterol levels

near HLA-DQB1 · rs3134988

What the study found

Who was studied 146,492 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0506 lower (95% confidence interval 0.037-0.064); p = 1 × 10−11.

How common The A allele had a frequency of about 81% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 4.6 kb from HLA-DQB1.

What each result means

A/A Two copies of the version the research linked to Non-HDL cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Non-HDL cholesterol levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Non-HDL cholesterol levels. This is the starting point the study compared everyone against.
Source

Questions about rs3134988

What is rs3134988?

rs3134988 is a single position in the genome, in or near the near HLA-DQB1 gene. Published research associates it with non-hdl cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3134988 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3134988 come from?

GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Non-HDL cholesterol levels (rs3134988). MyGeneLog™. https://www.mygenelog.com/variants/rs3134988

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