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Hemoglobin concentration

NOTCH4 · rs3132956

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 46,904 European ancestry males; replicated in 80,822 European ancestry males.

The effect Each copy of the A allele shifted the measure 0.0483 lower; p = 2 × 10⁻²⁰.

How common The A allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in an intron of NOTCH4.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hemoglobin concentration compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hemoglobin concentration.

G/G Published research associates this genotype with typical/baseline likelihood of Hemoglobin concentration — no copies of the reported risk allele.

Source

Common and ethnic-specific genetic determinants of hemoglobin concentration between Taiwanese Han Chinese and European Whites: findings from comparative two-stage genome-wide association studies

Timoteo VJ, Chiang KM, Yang HC, Pan WH

The Journal of nutritional biochemistry · 2023 · PMID 35964923

Questions about rs3132956

What is rs3132956?

rs3132956 is a single position in the genome, in or near the NOTCH4 gene. Published research associates it with hemoglobin concentration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3132956 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3132956 come from?

GWAS Catalog, The Journal of nutritional biochemistry 2023, PMID:35964923. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hemoglobin concentration (rs3132956). MyGeneLog™. https://www.mygenelog.com/variants/rs3132956

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