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MHC class I polypeptide-related sequence B levels

PSORS1C1 · rs3130991

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 997 European ancestry individuals; replicated in 338 Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian ancestry, Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.361 higher (95% confidence interval 0.27-0.45); p = 4 × 10⁻¹⁵.

Where it sits Chromosome 6, band 6p21.33 — in an intron of PSORS1C1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of MHC class I polypeptide-related sequence B levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with MHC class I polypeptide-related sequence B levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of MHC class I polypeptide-related sequence B levels compared to the general population.

Source

Connecting genetic risk to disease end points through the human blood plasma proteome

Suhre K, Arnold M, Bhagwat AM, Cotton RJ, Engelke R, Raffler J, Sarwath H, Thareja G, Wahl A, DeLisle RK, Gold L, Pezer M

and 12 more — show all

Lauc G, El-Din Selim MA, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J

Nature communications · 2017 · PMID 28240269 · open access

Questions about rs3130991

What is rs3130991?

rs3130991 is a single position in the genome, in or near the PSORS1C1 gene. Published research associates it with mhc class i polypeptide-related sequence b levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3130991 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3130991 come from?

GWAS Catalog, Nature communications 2017, PMID:28240269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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MHC class I polypeptide-related sequence B levels (rs3130991). MyGeneLog™. https://www.mygenelog.com/variants/rs3130991

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