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Its strongest genetic-study result is p = 10−21, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 10,799 European, East Asian, African, South Asian, Middle Eastern, Admixed or unknown ancestry cases, 487,324 European, East Asian, African, South Asian, Middle Eastern, Admixed or unknown ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.171 log odds ratio lower (95% confidence interval 0.14-0.21); p = 3 × 10−21.
What each result means
C/CNo copy of the version the research linked to Hashimoto thyroiditis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Hashimoto thyroiditis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Hashimoto thyroiditis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 42527560 · open access
Questions about rs3130977
What is rs3130977?
rs3130977 is a single position in the genome, in or near the near PSORS1C1 gene. Published research associates it with hashimoto thyroiditis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3130977 linked to?
On MyGeneLog this position is linked to Lymphocytic Thyroiditis (Hashimoto's). The research behind each link, and its sources, are set out on that condition page.
Does having rs3130977 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3130977 come from?
GWAS Catalog, Nature genetics 2026, PMID:42527560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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