Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome)
TRIM27 · rs3130895
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Who was studied 664 Swedish ancestry non-Lofgren's syndrome cases, 384 Swedish ancestry Lofgren's syndrome cases; replicated in 413 German ancestry non-Lofgren's syndrome cases, 64 German ancestry Lofgren's syndrome cases.
The effect
The reported allele is A; the catalogue records no effect size
; p = 4 × 10−19.
How common The A allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 6, band 6p22.1 — in an intron of LINC01556.
What each result means
A/ATwo copies of the version the research linked to Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome). This is the starting point the study compared everyone against.
American journal of respiratory and critical care medicine · 2016 · PMID 26651848
Questions about rs3130895
What is rs3130895?
rs3130895 is a single position in the genome, in or near the TRIM27 gene. Published research associates it with sarcoidosis (lofgren's syndrome vs non-lofgren's syndrome). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3130895 linked to?
On MyGeneLog this position is linked to Sarcoidosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs3130895 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3130895 come from?
GWAS Catalog, American journal of respiratory and critical care medicine 2016, PMID:26651848. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) (rs3130895). MyGeneLog™. https://www.mygenelog.com/variants/rs3130895