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Cardiometabolic and hematological traits

ZNF311 · rs3130725

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied up to 35,981 European ancestry individuals; replicated in up to 102,505 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.008 lower (95% confidence interval 0.006-0.01); p = 3 × 10−26.

Where it sits Chromosome 6, band 6p22.1 — between genes, 12.2 kb from OR2N1P.

What each result means

G/G Two copies of the version the research linked to Cardiometabolic and hematological traits. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Cardiometabolic and hematological traits. That is a smaller link than two copies.
T/T No copy of the version the research linked to Cardiometabolic and hematological traits. This is the starting point the study compared everyone against.
Source
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C, Walter K, Min JL, Chen L, Astle W, Cocca M, Deelen P, Elding H
and 55 more — show all
Farmaki AE, Franklin CS, Franberg M, Gaunt TR, Hofman A, Jiang T, Kleber ME, Lachance G, Luan J, Malerba G, Matchan A, Mead D, Memari Y, Ntalla I, Panoutsopoulou K, Pazoki R, Perry JRB, Rivadeneira F, Sabater-Lleal M, Sennblad B, Shin SY, Southam L, Traglia M, van Dijk F, van Leeuwen EM, Zaza G, Zhang W, Amin N, Butterworth A, Chambers JC, Dedoussis G, Dehghan A, Franco OH, Franke L, Frontini M, Gambaro G, Gasparini P, Hamsten A, Issacs A, Kooner JS, Kooperberg C, Langenberg C, Marz W, Scott RA, Swertz MA, Toniolo D, Uitterlinden AG, van Duijn CM, Watkins H, Zeggini E, Maurano MT, Timpson NJ, Reiner AP, Auer PL, Soranzo N
UK10K Consortium
Nature genetics · 2016 · PMID 27668658

Questions about rs3130725

What is rs3130725?

rs3130725 is a single position in the genome, in or near the ZNF311 gene. Published research associates it with cardiometabolic and hematological traits. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3130725 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3130725 come from?

GWAS Catalog, Nature genetics 2016, PMID:27668658. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cardiometabolic and hematological traits (rs3130725). MyGeneLog™. https://www.mygenelog.com/variants/rs3130725

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