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Hemoglobin concentration

near PSORS1C1 · rs3130552

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 52,141 European ancestry females; replicated in 89,584 European ancestry females.

The effect Each copy of the A allele shifted the measure 0.0324 lower; p = 5 × 10⁻²¹.

How common The A allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 0.4 kb from PSORS1C1.

What each result means

A/A Two copies of the version the research linked to Hemoglobin concentration. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Hemoglobin concentration. That is a smaller link than two copies.

G/G No copy of the version the research linked to Hemoglobin concentration. This is the starting point the study compared everyone against.

Source

Common and ethnic-specific genetic determinants of hemoglobin concentration between Taiwanese Han Chinese and European Whites: findings from comparative two-stage genome-wide association studies

Timoteo VJ, Chiang KM, Yang HC, Pan WH

The Journal of nutritional biochemistry · 2023 · PMID 35964923

In the news

2026-07-29 · Bujnis MN, et al. Nature Genetics 2026, PMID:42527560

Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto's thyroiditis

Bujnis MN, et al. (Nature Genetics, 2026) is newly in the GWAS Catalog, with 422 associations across 1 trait ("Hashimoto thyroiditis"). The catalogue records its sample as 47,104 cases and 1,037,695 controls. Of its 299 positions, 93 already have pages here — 20 on the Hypothyroidism page; 20 on the Hashimoto Thyroiditis page; 5 on the Thyroid Stimulating Hormone (TSH) Levels page — including rs3130552 (near PSORS1C1), rs1230666 (MAG13), rs231725 (CTLA4). Everything above is from the catalogue's records, assembled by code; the paper itself is linked. PMID:42527560.

Questions about rs3130552

What is rs3130552?

rs3130552 is a single position in the genome, in or near the near PSORS1C1 gene. Published research associates it with hemoglobin concentration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3130552 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3130552 come from?

GWAS Catalog, The Journal of nutritional biochemistry 2023, PMID:35964923. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hemoglobin concentration (rs3130552). MyGeneLog™. https://www.mygenelog.com/variants/rs3130552

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