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Psoriasis

HLA-DPA2 · rs3130192

Where this position leads

Condition: Psoriasis

rs3130192 Condition: Psoriasis Psoriasis Condition rs3130192 rs3130192 HLA-DPA2

What the study found

Who was studied 26,279 European ancestry cases, 442,230 European ancestry controls, 2,590 South Asian ancestry cases, 1,720 South Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0971 lower (95% confidence interval 0.072-0.122); p = 2 × 10−10.

Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DPA2.

What each result means

C/C No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs3130192

What is rs3130192?

rs3130192 is a single position in the genome, in or near the HLA-DPA2 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3130192 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs3130192 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3130192 come from?

GWAS Catalog, Journal of translational medicine 2025, PMID:39885523. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs3130192). MyGeneLog™. https://www.mygenelog.com/variants/rs3130192

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