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Neutrophil count

HLA-DPA2 · rs3130189

What the study found

Who was studied 234,802 European ancestry individuals; replicated in 100,556 European ancestry individuals.

The effect The reported allele is T; the catalogue records no effect size ; p = 9 × 10−13.

How common The T allele had a frequency of about 83% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DPA2.

What each result means

C/C No copy of the version the research linked to Neutrophil count. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Neutrophil count. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Neutrophil count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs3130189

What is rs3130189?

rs3130189 is a single position in the genome, in or near the HLA-DPA2 gene. Published research associates it with neutrophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3130189 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3130189 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:34469753. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Neutrophil count (rs3130189). MyGeneLog™. https://www.mygenelog.com/variants/rs3130189

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