Sensitive

Depression (broad)

near RPP21 · rs3130116

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹², with 6 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 113,769 British ancestry cases, 208,811 British ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0124 lower (95% confidence interval 0.0091-0.0157); p = 6 × 10⁻¹³.

How common The C allele had a frequency of about 14% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — between genes, 17 kb from MICC.

How common each version is

CT

Korean KRGDB

C 1.1% · T 98.9%

Korean Korea4K

C 1.2% · T 98.8%

Japanese ToMMo

T 100.0%

World gnomAD

C 7.2% · T 92.8%

World 1000 Genomes

C 3.0% · T 97.0%

World TOPMed

C 6.9% · T 93.1%

By ancestry gnomAD

East Asian

T 99.9%

European (non-Finnish)

C 11.2% · T 88.8%

African / African American

C 4.3% · T 95.7%

South Asian

T 99.9%

Admixed American (Latino)

C 3.2% · T 96.8%

Middle Eastern

C 2.0% · T 98.0%

Finnish

C 7.1% · T 92.9%

Ashkenazi Jewish

C 3.0% · T 97.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C Two copies of the version the research linked to Depression (broad). That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Depression (broad). That is a smaller link than two copies.

T/T No copy of the version the research linked to Depression (broad). This is the starting point the study compared everyone against.

Source

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, Coleman JRI, Alloza C, Shen X, Barbu MC, Wigmore EM, Gibson J

and 9 more — show all

Hagenaars SP, Lewis CM, Ward J, Smith DJ, Sullivan PF, Haley CS, Breen G, Deary IJ, McIntosh AM

23andMe Research Team

Nature communications · 2018 · PMID 29662059 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Depression (broad) (rs3130116). MyGeneLog™. https://www.mygenelog.com/variants/rs3130116

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