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Hidradenitis suppurativa

HLA-DRA · rs3129879

Where this position leads

Condition: Hidradenitis Suppurativa

rs3129879 Condition: Hidradenitis Suppurativa Hidradenitis Suppurativa Condition rs3129879 rs3129879 HLA-DRA

What the study found

Who was studied 2,864 European ancestry cases, 1,315,903 European ancestry controls, 1,077 African ancestry cases, 119,700 African ancestry controls.

The effect Each copy of the A allele carried 0.82 times the odds of Hidradenitis suppurativa (95% confidence interval 0.77-0.86); p = 1 × 10−12.

How common The A allele had a frequency of about 40% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DRA.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hidradenitis suppurativa compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hidradenitis suppurativa.
G/G Published research associates this genotype with typical/baseline likelihood of Hidradenitis suppurativa — no copies of the reported risk allele.
Source
Multiomics analyses prioritize disease genes and pathways in hidradenitis suppurativa
Peacker BL, Ly L, Hwang JC, Gravel-Pucillo K, Zheng C, Wheless LE, Ferolito BR, Cho K, Gaziano JM, Pereira AC, Hartman RI
The Journal of investigative dermatology · 2026 · PMID 41548865

Questions about rs3129879

What is rs3129879?

rs3129879 is a single position in the genome, in or near the HLA-DRA gene. Published research associates it with hidradenitis suppurativa. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3129879 linked to?

On MyGeneLog this position is linked to Hidradenitis Suppurativa. The research behind each link, and its sources, are set out on that condition page.

Does having rs3129879 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3129879 come from?

GWAS Catalog, The Journal of investigative dermatology 2026, PMID:41548865. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hidradenitis suppurativa (rs3129879). MyGeneLog™. https://www.mygenelog.com/variants/rs3129879

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