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Free cholesterol to total lipids ratio in very large VLDL

HLA-DQA1 · rs3129774

What the study found

Who was studied 114,160 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0397 higher (95% confidence interval 0.032-0.048); p = 2 × 10−21.

How common The C allele had a frequency of about 56% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — inside HLA-DQA1.

What each result means

C/C Two copies of the version the research linked to Free cholesterol to total lipids ratio in very large VLDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Free cholesterol to total lipids ratio in very large VLDL. That is a smaller link than two copies.
T/T No copy of the version the research linked to Free cholesterol to total lipids ratio in very large VLDL. This is the starting point the study compared everyone against.
Source

Questions about rs3129774

What is rs3129774?

rs3129774 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with free cholesterol to total lipids ratio in very large vldl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3129774 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3129774 come from?

GWAS Catalog, PLoS biology 2022, PMID:35213538. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Free cholesterol to total lipids ratio in very large VLDL (rs3129774). MyGeneLog™. https://www.mygenelog.com/variants/rs3129774

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