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Who was studied 1,286 European ancestry cases, 6,193 European ancestry non-Hodgkin lymphoma childhood cancer cases, 369 European ancestry non-cancer controls.
The effect
Each copy of the A allele carried 1.54 times the odds of Hodgkin's lymphoma (95% confidence interval 1.39-1.72); p = 3 × 10−15.
Where it sits Chromosome 6, band 6p21.32 — between genes, 0.7 kb from COL11A2P1.
What each result means
A/ATwo copies of the version the research linked to Hodgkin's lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Hodgkin's lymphoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Hodgkin's lymphoma. This is the starting point the study compared everyone against.
JAMA network open · 2022 · PMID 35939300 · open access
Questions about rs3129198
What is rs3129198?
rs3129198 is a single position in the genome, in or near the near COL11A2P1 gene. Published research associates it with hodgkin's lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3129198 linked to?
On MyGeneLog this position is linked to Hodgkin Lymphoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs3129198 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3129198 come from?
GWAS Catalog, JAMA network open 2022, PMID:35939300. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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