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Creatinine levels

SLC22A2 · rs3127573

Where this position leads

What the study found

Who was studied 23,812 European ancestry individuals; replicated in 16,626 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 1.1 % higher (95% confidence interval 0.8-1.4); p = 7 × 10⁻¹⁰.

How common The G allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 6, band 6q25.3 — in the 5′ untranslated region of SLC22A2.

What each result means

A/A No copy of the version the research linked to Creatinine levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Creatinine levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Creatinine levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genetic loci influencing kidney function and chronic kidney disease

Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJ, Beckmann J, Bilo HJ

and 82 more — show all

Bochud M, Brown MJ, Caulfield MJ, Connell JM, Cook HT, Cotlarciuc I, Davey Smith G, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Ferrucci L, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, Homan van der Heide JJ, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJ, Luan J, Luttropp K, Maréchal C, Melander O, Munroe PB, Nordfors L, Parsa A, Peltonen L, Penninx BW, Perucha E, Pouta A, Prokopenko I, Roderick PJ, Ruokonen A, Samani NJ, Sanna S, Schalling M, Schlessinger D, Schlieper G, Seelen MA, Shuldiner AR, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJ, Swaminathan R, Tanaka T, Ubink-Veltmaat LJ, Uda M, Vollenweider P, Wallace C, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin MR, Mooser V, Abecasis GR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JS

Nature genetics · 2010 · PMID 20383145

What people read about alongside this

Kidneys1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs3127573

What is rs3127573?

rs3127573 is a single position in the genome, in or near the SLC22A2 gene. Published research associates it with creatinine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3127573 linked to?

On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs3127573?

Subjects that appear in the title or abstract of the same papers as this rsID include kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs3127573 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3127573 come from?

GWAS Catalog, Nat Genet 2010, PMID:20383145. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Creatinine levels (rs3127573). MyGeneLog™. https://www.mygenelog.com/variants/rs3127573

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