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Primary sclerosing cholangitis (MTAG)

PSORS1C1 · rs3094210

Where this position leads

Condition: Primary Sclerosing Cholangitis

rs3094210 Condition: Primary Sclerosing Cholangitis Primary Sclerosing Cholangitis Condition rs3094210 rs3094210 PSORS1C1

What the study found

Who was studied at least 2,871 European ancestry cases, at least 12,019 European ancestry controls (MTAG boosted by autoimmune-related disease samples); replicated in at least 952 cases, 231,644 controls (MTAG boosted by autoimmune-related disease samples).

The effect Each copy of the A allele shifted the measure 0.177 higher (95% confidence interval 0.16-0.2); p = 1 × 10−61.

Where it sits Chromosome 6, band 6p21.33 — in an intron of PSORS1C1.

What each result means

A/A Two copies of the version the research linked to Primary sclerosing cholangitis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Primary sclerosing cholangitis (MTAG). That is a smaller link than two copies.
G/G No copy of the version the research linked to Primary sclerosing cholangitis (MTAG). This is the starting point the study compared everyone against.
Source

Questions about rs3094210

What is rs3094210?

rs3094210 is a single position in the genome, in or near the PSORS1C1 gene. Published research associates it with primary sclerosing cholangitis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3094210 linked to?

On MyGeneLog this position is linked to Primary Sclerosing Cholangitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs3094210 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3094210 come from?

GWAS Catalog, Nature communications 2023, PMID:36828809. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Primary sclerosing cholangitis (MTAG) (rs3094210). MyGeneLog™. https://www.mygenelog.com/variants/rs3094210

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