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Polyunsaturated fatty acid levels

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹³, with 17 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 115,006 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0444 higher (95% confidence interval 0.033-0.056); p = 2 × 10⁻¹³.

How common The G allele had a frequency of about 87% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — in an intron of POLR1HASP.

How common each version is

CG

World gnomAD

C 5.9% · G 94.1%

World 1000 Genomes

C 2.2% · G 97.8%

World TOPMed

C 5.6% · G 94.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. No Korean figure for this position yet.

What each result means

C/C No copy of the version the research linked to Polyunsaturated fatty acid levels. This is the starting point the study compared everyone against.

C/G One copy of the version the research linked to Polyunsaturated fatty acid levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Polyunsaturated fatty acid levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation

Richardson TG, Leyden GM, Wang Q, Bell JA, Elsworth B, Davey Smith G, Holmes MV

PLoS biology · 2022 · PMID 35213538 · open access

Questions about rs3094146

What is rs3094146?

rs3094146 is a single position in the genome, in or near the POLR1HASP gene. Published research associates it with polyunsaturated fatty acid levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3094146 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3094146 come from?

GWAS Catalog, PLoS biology 2022, PMID:35213538. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Polyunsaturated fatty acid levels (rs3094146). MyGeneLog™. https://www.mygenelog.com/variants/rs3094146

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