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Allergic disease (asthma, hay fever and/or eczema) (age of onset)

MBD2 · rs3017289

Where this position leads

Condition: Asthma

rs3017289 Condition: Asthma Asthma Condition rs3017289 rs3017289 MBD2

What the study found

Who was studied 117,130 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.029 lower (95% confidence interval 0.019-0.039); p = 2 × 10−10.

How common The C allele had a frequency of about 29% in the people studied.

Where it sits Chromosome 18, band 18q21.2 — between genes, 15.5 kb from POLI.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Allergic disease (asthma, hay fever and/or eczema) (age of onset) — no copies of the reported risk allele.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Allergic disease (asthma, hay fever and/or eczema) (age of onset).
C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Allergic disease (asthma, hay fever and/or eczema) (age of onset) compared to the general population.
Source
Age-of-onset information helps identify 76 genetic variants associated with allergic disease
Ferreira MAR, Vonk JM, Baurecht H, Marenholz I, Tian C, Hoffman JD, Helmer Q, Tillander A, Ullemar V, Lu Y, Grosche S, Rüschendorf F
and 28 more — show all
Granell R, Brumpton BM, Fritsche LG, Bhatta L, Gabrielsen ME, Nielsen JB, Zhou W, Hveem K, Langhammer A, Holmen OL, Løset M, Abecasis GR, Willer CJ, Emami NC, Cavazos TB, Witte JS, Szwajda A, Hinds DA, Hübner N, Weidinger S, Magnusson PK, Jorgenson E, Karlsson R, Paternoster L, Boomsma DI, Almqvist C, Lee YA, Koppelman GH
23andMe Research Team · collaborators of the SHARE study
PLoS genetics · 2020 · PMID 32603359 · open access

Questions about rs3017289

What is rs3017289?

rs3017289 is a single position in the genome, in or near the MBD2 gene. Published research associates it with allergic disease (asthma, hay fever and/or eczema) (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3017289 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs3017289 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3017289 come from?

GWAS Catalog, PLoS genetics 2020, PMID:32603359. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Allergic disease (asthma, hay fever and/or eczema) (age of onset) (rs3017289). MyGeneLog™. https://www.mygenelog.com/variants/rs3017289

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