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Thyroid stimulating hormone levels

PDE10A · rs3008034

Where this position leads

Condition: Thyroid Stimulating Hormone (TSH) Levels

rs3008034 Condition: Thyroid Stimulating Hormone (TSH) Levels Thyroid Stimulating Hormone (TSH) Levels Condition rs3008034 rs3008034 PDE10A

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Thyroid stimulating hormone levels compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Thyroid stimulating hormone levels.
T/T Published research associates this genotype with typical/baseline likelihood of Thyroid stimulating hormone levels — no copies of the reported risk allele.
Source
Whole-genome sequence-based analysis of thyroid function
Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA, Min J, Walter K, Memari Y, Huang J
and 38 more — show all
Barnes MR, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta V, Greenwood C, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman D, Panicker V, Perry JR, Bell JT, Yuan W, Relton C, Gaunt T, Schlessinger D, Abecasis G, Cucca F, Surdulescu GL, Woltersdorf W, Zeggini E, Zheng HF, Toniolo D, Dayan CM, Naitza S, Walsh JP, Spector T, Davey Smith G, Durbin R, Richards JB, Sanna S, Soranzo N, Timpson NJ, Wilson SG
UK0K Consortium
Nature communications · 2015 · PMID 25743335 · open access

Questions about rs3008034

What is rs3008034?

rs3008034 is a single position in the genome, in or near the PDE10A gene. Published research associates it with thyroid stimulating hormone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3008034 linked to?

On MyGeneLog this position is linked to Thyroid Stimulating Hormone (TSH) Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs3008034 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3008034 come from?

GWAS Catalog, Nat Commun 2015, PMID:25743335. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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