Standard

Forced vital capacity (FVC)

ZNF438 · rs2994657

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

rs2994657 Condition: Pulmonary Function (Lung Capacity) Pulmonary Function (Lung Capacity) Condition rs2994657 rs2994657 ZNF438

What the study found

Who was studied 129,680 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0194 higher (95% confidence interval 0.013-0.026); p = 8 × 10−10.

Where it sits Chromosome 10, band 10p11.23 — inside ZNF438.

What each result means

C/C Two copies of the version the research linked to Forced vital capacity (FVC). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Forced vital capacity (FVC). That is a smaller link than two copies.
T/T No copy of the version the research linked to Forced vital capacity (FVC). This is the starting point the study compared everyone against.
Source

Questions about rs2994657

What is rs2994657?

rs2994657 is a single position in the genome, in or near the ZNF438 gene. Published research associates it with forced vital capacity (fvc). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2994657 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

Does having rs2994657 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2994657 come from?

GWAS Catalog, Nature genetics 2026, PMID:41565855. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Forced vital capacity (FVC) (rs2994657). MyGeneLog™. https://www.mygenelog.com/variants/rs2994657

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