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Angiopoietin-1 receptor, soluble protein levels (SomaScan ID:2844-53)

TIE1 · rs2991990

What the study found

Who was studied 200 Shetland Isles origin ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.596 higher (95% confidence interval 0.37-0.83); p = 2 × 10−11.

Where it sits Chromosome 1, band 1p34.2 — in an intron of TIE1.

What each result means

G/G Two copies of the version the research linked to Angiopoietin-1 receptor, soluble protein levels (SomaScan ID:2844-53). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Angiopoietin-1 receptor, soluble protein levels (SomaScan ID:2844-53). That is a smaller link than two copies.
T/T No copy of the version the research linked to Angiopoietin-1 receptor, soluble protein levels (SomaScan ID:2844-53). This is the starting point the study compared everyone against.
Source

Questions about rs2991990

What is rs2991990?

rs2991990 is a single position in the genome, in or near the TIE1 gene. Published research associates it with angiopoietin-1 receptor, soluble protein levels (somascan id:2844-53). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2991990 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2991990 come from?

GWAS Catalog, Communications biology 2025, PMID:40883583. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Angiopoietin-1 receptor, soluble protein levels (SomaScan ID:2844-53) (rs2991990). MyGeneLog™. https://www.mygenelog.com/variants/rs2991990

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