Sensitive

Thyroid cancer

near LINC02950 · rs2979241

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻²⁹, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 6,056 European ancestry cases, 907,977 European ancestry controls, 4,661 East Asian ancestry cases, 354,129 East Asian ancestry controls, 5,450 African, Admixed American, European, East Asian, South Asian or unknown ancestry cases, 1,168,268 African, Admixed American, European, East Asian, South Asian or unknown ancestry controls.

The effect Each copy of the C allele shifted the measure 0.147 higher (95% confidence interval 0.12-0.17); p = 2 × 10⁻²⁹.

Where it sits Chromosome 8, band 8p23.1 — between genes, 3.8 kb from LINC02950.

How common each version is

CG

By ancestry gnomAD

East Asian

C 87.4% · G 12.6%

European (non-Finnish)

C 49.5% · G 50.5%

African / African American

C 29.0% · G 71.0%

South Asian

C 62.2% · G 37.8%

Admixed American (Latino)

C 62.8% · G 37.2%

Middle Eastern

C 42.8% · G 57.2%

Finnish

C 60.6% · G 39.4%

Ashkenazi Jewish

C 36.8% · G 63.2%

The share of all copies of this position that are each version. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C Two copies of the version the research linked to Thyroid cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Thyroid cancer. That is a smaller link than two copies.

G/G No copy of the version the research linked to Thyroid cancer. This is the starting point the study compared everyone against.

DNA databases also record a third, rare version at this position, carried on fewer than one in a hundred copies of the DNA. The three results above cover the two common versions only.

Source

Genetic drivers of etiologic heterogeneity in thyroid cancer

Jee YH, Pozdeyev N, Gignoux CR, White S, Haugen BR, Verma A, Peculis R, Rovite V, Mulford AJ, Sanders AR, Kitahara CM, Reeve MP

and 2 more — show all

Kraft P, Martin AR

Nature communications · 2026 · PMID 42431967 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Thyroid cancer (rs2979241). MyGeneLog™. https://www.mygenelog.com/variants/rs2979241

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