ARHGEF28 · rs2973549
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 6,436 European ancestry cases, 96,601 European ancestry controls.
The effect Each copy of the A allele shifted the measure 0.11 higher (95% confidence interval 0.071-0.149); p = 1 × 10−8.
How common The A allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 5, band 5q13.2 — in an intron of ARHGEF28.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-06-18.
ClinVar record 1244210 NM_001177693.2(ARHGEF28):c.964-30T>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2973549 is a single position in the genome, in or near the ARHGEF28 gene. Published research associates it with hearing aid use. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, European journal of human genetics : EJHG 2023, PMID:36788145. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hearing aid use (rs2973549). MyGeneLog™. https://www.mygenelog.com/variants/rs2973549