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Offspring birth weight

GCK · rs2971669

Where this position leads

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Offspring birth weight — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Offspring birth weight.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Offspring birth weight compared to the general population.

Source

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, Bradfield JP, Kreiner-Møller E

and 74 more — show all

Huikari V, Metrustry S, Lunetta KL, Painter JN, Hottenga JJ, Allard C, Barton SJ, Espinosa A, Marsh JA, Potter C, Zhang G, Ang W, Berry DJ, Bouchard L, Das S, Hakonarson H, Heikkinen J, Helgeland Ø, Hocher B, Hofman A, Inskip HM, Jones SE, Kogevinas M, Lind PA, Marullo L, Medland SE, Murray A, Murray JC, Njølstad PR, Nohr EA, Reichetzeder C, Ring SM, Ruth KS, Santa-Marina L, Scholtens DM, Sebert S, Sengpiel V, Tuke MA, Vaudel M, Weedon MN, Willemsen G, Wood AR, Yaghootkar H, Muglia LJ, Bartels M, Relton CL, Pennell CE, Chatzi L, Estivill X, Holloway JW, Boomsma DI, Montgomery GW, Murabito JM, Spector TD, Power C, Järvelin MR, Bisgaard H, Grant SFA, Sørensen TIA, Jaddoe VW, Jacobsson B, Melbye M, McCarthy MI, Hattersley AT, Hayes MG, Frayling TM, Hivert MF, Felix JF, Hyppönen E, Lowe WL Jr, Evans DM, Lawlor DA, Feenstra B, Freathy RM

Early Growth Genetics (EGG) Consortium

Human molecular genetics · 2018 · PMID 29309628 · open access

Questions about rs2971669

What is rs2971669?

rs2971669 is a single position in the genome, in or near the GCK gene. Published research associates it with offspring birth weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2971669 linked to?

On MyGeneLog this position is linked to Birth Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs2971669 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2971669 come from?

GWAS Catalog, Hum Mol Genet 2018, PMID:29309628. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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