Who was studied 24,087 European ancestry late-onset Alzheimer's disease cases, 47,793 European ancestry individuals with family history of Alzheimer's disease, 383,378 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 10.3 z-unit lower; p = 7 × 10−25.
How common The G allele had a frequency of about 11% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — in an intron of CBLC.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Alzheimer's disease or family history of Alzheimer's disease — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alzheimer's disease or family history of Alzheimer's disease.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alzheimer's disease or family history of Alzheimer's disease compared to the general population.
rs2967668 is a single position in the genome, in or near the CBLC gene. Published research associates it with alzheimer's disease or family history of alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2967668 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs2967668 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2967668 come from?
GWAS Catalog, Nat Genet 2019, PMID:30617256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0
11
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease or family history of Alzheimer's disease (rs2967668). MyGeneLog™. https://www.mygenelog.com/variants/rs2967668