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5alpha-pregnan-3(alpha or beta),20beta-diol disulfate levels

near SULT2A1 · rs296373

What the study found

Who was studied 14,296 European ancestry individuals; replicated in 5,698 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.174 lower (95% confidence interval 0.13-0.22); p = 3 × 10−16.

How common The A allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 19, band 19q13.33 — between genes, 8.4 kb from SULT2A1.

What each result means

A/A Two copies of the version the research linked to 5alpha-pregnan-3(alpha or beta),20beta-diol disulfate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to 5alpha-pregnan-3(alpha or beta),20beta-diol disulfate levels. That is a smaller link than two copies.
C/C No copy of the version the research linked to 5alpha-pregnan-3(alpha or beta),20beta-diol disulfate levels. This is the starting point the study compared everyone against.
Source

Questions about rs296373

What is rs296373?

rs296373 is a single position in the genome, in or near the near SULT2A1 gene. Published research associates it with 5alpha-pregnan-3(alpha or beta),20beta-diol disulfate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs296373 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs296373 come from?

GWAS Catalog, Nature medicine 2022, PMID:36357675. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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5alpha-pregnan-3(alpha or beta),20beta-diol disulfate levels (rs296373). MyGeneLog™. https://www.mygenelog.com/variants/rs296373

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