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Standard

Height

TRIB1AL · rs2954025

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10−50, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 5,314,291 European ancestry, Hispanic or Latin American, East Asian ancestry, African ancestry, South Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0105 lower (95% confidence interval 0.0091-0.0119); p = 4 × 10−51.

How common The C allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 8, band 8q24.13 — in an intron of TRIB1AL.

How common each version is

CT

By ancestry gnomAD

East Asian
C 32.1% · T 67.9%
European (non-Finnish)
C 35.5% · T 64.5%
African / African American
C 40.7% · T 59.3%
South Asian
C 33.0% · T 67.0%
Admixed American (Latino)
C 37.5% · T 62.5%
Middle Eastern
C 48.6% · T 51.4%
Finnish
C 34.6% · T 65.3%
Ashkenazi Jewish
C 47.1% · T 52.9%

The share of all copies of this position that are each version. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Height. That is a smaller link than two copies.
T/T No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
DNA databases also record a third, rare version at this position, carried on fewer than one in a hundred copies of the DNA. The three results above cover the two common versions only.
Source

Quoting this page

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Height (rs2954025). MyGeneLog™. https://www.mygenelog.com/variants/rs2954025

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