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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied Up to 52,350 European ancestry individuals, up to 8,739 Indian Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 1.6 % higher (95% confidence interval 0.60-2.60); p = 5 × 10−9.
How common The A allele had a frequency of about 50% in the people studied.
Where it sits Chromosome 8, band 8q24.13 — in an intron of TRIB1AL.
What each result means
A/ATwo copies of the version the research linked to Liver enzyme levels (alanine transaminase). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Liver enzyme levels (alanine transaminase). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Liver enzyme levels (alanine transaminase). This is the starting point the study compared everyone against.
rs2954021 is a single position in the genome, in or near the TRIB1 gene. Published research associates it with liver enzyme levels (alanine transaminase). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2954021 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2954021 come from?
GWAS Catalog, Nat Genet 2011, PMID:22001757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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