Standard
Liver enzyme levels (alanine transaminase)
TRIB1 · rs2954021
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Liver enzyme levels (alanine transaminase) compared to the general population. (GWAS Catalog, Nat Genet 2011, PMID:22001757)
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Liver enzyme levels (alanine transaminase). (GWAS Catalog, Nat Genet 2011, PMID:22001757)
G/G
Published research associates this genotype with typical/baseline likelihood of Liver enzyme levels (alanine transaminase) — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2011, PMID:22001757)
Source
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Chambers JC,
Zhang W,
Sehmi J,
Li X,
Wass MN,
Van der Harst P,
Holm H,
Sanna S,
Kavousi M,
Baumeister SE,
Coin LJ,
Deng G
and 124 more — show all
Gieger C,
Heard-Costa NL,
Hottenga JJ,
Kühnel B,
Kumar V,
Lagou V,
Liang L,
Luan J,
Vidal PM,
Mateo Leach I,
O'Reilly PF,
Peden JF,
Rahmioglu N,
Soininen P,
Speliotes EK,
Yuan X,
Thorleifsson G,
Alizadeh BZ,
Atwood LD,
Borecki IB,
Brown MJ,
Charoen P,
Cucca F,
Das D,
de Geus EJ,
Dixon AL,
Döring A,
Ehret G,
Eyjolfsson GI,
Farrall M,
Forouhi NG,
Friedrich N,
Goessling W,
Gudbjartsson DF,
Harris TB,
Hartikainen AL,
Heath S,
Hirschfield GM,
Hofman A,
Homuth G,
Hyppönen E,
Janssen HL,
Johnson T,
Kangas AJ,
Kema IP,
Kühn JP,
Lai S,
Lathrop M,
Lerch MM,
Li Y,
Liang TJ,
Lin JP,
Loos RJ,
Martin NG,
Moffatt MF,
Montgomery GW,
Munroe PB,
Musunuru K,
Nakamura Y,
O'Donnell CJ,
Olafsson I,
Penninx BW,
Pouta A,
Prins BP,
Prokopenko I,
Puls R,
Ruokonen A,
Savolainen MJ,
Schlessinger D,
Schouten JN,
Seedorf U,
Sen-Chowdhry S,
Siminovitch KA,
Smit JH,
Spector TD,
Tan W,
Teslovich TM,
Tukiainen T,
Uitterlinden AG,
Van der Klauw MM,
Vasan RS,
Wallace C,
Wallaschofski H,
Wichmann HE,
Willemsen G,
Würtz P,
Xu C,
Yerges-Armstrong LM,
Abecasis GR,
Ahmadi KR,
Boomsma DI,
Caulfield M,
Cookson WO,
van Duijn CM,
Froguel P,
Matsuda K,
McCarthy MI,
Meisinger C,
Mooser V,
Pietiläinen KH,
Schumann G,
Snieder H,
Sternberg MJ,
Stolk RP,
Thomas HC,
Thorsteinsdottir U,
Uda M,
Waeber G,
Wareham NJ,
Waterworth DM,
Watkins H,
Whitfield JB,
Witteman JC,
Wolffenbuttel BH,
Fox CS,
Ala-Korpela M,
Stefansson K,
Vollenweider P,
Völzke H,
Schadt EE,
Scott J,
Järvelin MR,
Elliott P,
Kooner JS
Nature genetics · 2011 · PMID 22001757
Questions about rs2954021
What is rs2954021?
rs2954021 is a single position in the genome, in or near the TRIB1 gene. Published research associates it with liver enzyme levels (alanine transaminase). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2954021 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2954021 come from?
GWAS Catalog, Nat Genet 2011, PMID:22001757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants