Sensitive

Depression

TCF4 · rs2924329

Where this position leads

Condition: Endometriosis and Depression: Shared Genetics

rs2924329 Condition: Endometriosis and Depression: Shared Genetics Endometriosis and Depression: Share… Condition rs2924329 rs2924329 TCF4

What the study found

Who was studied at least 5,919 European ancestry cases, at least 130,691 European ancestry controls; replicated in 634,037 European ancestry cases, 1,308,690 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0181 higher (95% confidence interval 0.012-0.024); p = 5 × 10−13.

How common The G allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 18, band 18q21.2 — in an intron of TCF4.

What each result means

A/A No copy of the version the research linked to Depression. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Depression. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Depression. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2924329

What is rs2924329?

rs2924329 is a single position in the genome, in or near the TCF4 gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2924329 linked to?

On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.

Does having rs2924329 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2924329 come from?

GWAS Catalog, Nature human behaviour 2021, PMID:33859377. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Depression (rs2924329). MyGeneLog™. https://www.mygenelog.com/variants/rs2924329

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