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Eczema

NFILZ · rs2918299

Where this position leads

Condition: Atopic Dermatitis

rs2918299 Condition: Atopic Dermatitis Atopic Dermatitis Condition rs2918299 rs2918299 NFILZ

What the study found

Who was studied 20,016 European ancestry cases, 380,433 European ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 1 × 10−17.

How common The T allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 19, band 19p13.2 — a missense change in NFILZ.

What each result means

C/C No copy of the version the research linked to Eczema. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Eczema. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Eczema. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Grosche S, Marenholz I, Esparza-Gordillo J, Arnau-Soler A, Pairo-Castineira E, Rüschendorf F, Ahluwalia TS, Almqvist C, Arnold A, Baurecht H, Bisgaard H, Bønnelykke K
and 50 more — show all
Brown SJ, Bustamante M, Curtin JA, Custovic A, Dharmage SC, Esplugues A, Falchi M, Fernandez-Orth D, Ferreira MAR, Franke A, Gerdes S, Gieger C, Hakonarson H, Holt PG, Homuth G, Hubner N, Hysi PG, Jarvelin MR, Karlsson R, Koppelman GH, Lau S, Lutz M, Magnusson PKE, Marks GB, Müller-Nurasyid M, Nöthen MM, Paternoster L, Pennell CE, Peters A, Rawlik K, Robertson CF, Rodriguez E, Sebert S, Simpson A, Sleiman PMA, Standl M, Stölzl D, Strauch K, Szwajda A, Tenesa A, Thompson PJ, Ullemar V, Visconti A, Vonk JM, Wang CA, Weidinger S, Wielscher M, Worth CL, Xu CJ, Lee YA
Australian Asthma Genetics Consortium (AAGC)
Nature communications · 2021 · PMID 34785669 · open access

Questions about rs2918299

What is rs2918299?

rs2918299 is a single position in the genome, in or near the NFILZ gene. Published research associates it with eczema. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2918299 linked to?

On MyGeneLog this position is linked to Atopic Dermatitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs2918299 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2918299 come from?

GWAS Catalog, Nature communications 2021, PMID:34785669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Eczema (rs2918299). MyGeneLog™. https://www.mygenelog.com/variants/rs2918299

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