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Standard

What is your height? (cm, inv-normal transformed)

near SPRY4 · rs2908536

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 51,137 African American or Afro-Caribbean individuals, 27,055 Hispanic or Latin American individuals, 3,110 East Asian ancestry individuals, 283,251 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0274 higher (95% confidence interval 0.019-0.035); p = 2 × 10−11.

How common The A allele had a frequency of about 48% in the people studied.

Where it sits Chromosome 5, band 5q31.3 — between genes, 74.8 kb from SPRY4.

How common each version is

AG
Korean KRGDB
A 55.4% · G 44.6%
Korean Korea4K
A 54.9% · G 45.1%
Japanese ToMMo
A 53.9% · G 46.1%
Vietnamese
A 56.1% · G 43.9%
World gnomAD
A 48.6% · G 51.4%
World 1000 Genomes
A 47.1% · G 52.9%
World TOPMed
A 48.8% · G 51.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to What is your height? (cm, inv-normal transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to What is your height? (cm, inv-normal transformed). That is a smaller link than two copies.
G/G No copy of the version the research linked to What is your height? (cm, inv-normal transformed). This is the starting point the study compared everyone against.
Source

Quoting this page

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What is your height? (cm, inv-normal transformed) (rs2908536). MyGeneLog™. https://www.mygenelog.com/variants/rs2908536

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