Sensitive

Parkinson's disease or first degree relation to individual with Parkinson's disease

CD19 · rs2904880

Where this position leads

What the study found

Who was studied 15,056 European ancestry cases, 18,618 European ancestry proxy cases, 449,056 European ancestry controls; replicated in 22,632 European ancestry cases, 968,735 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.065 lower (95% confidence interval 0.044-0.086); p = 8 × 10⁻¹⁰.

How common The C allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 16, band 16p11.2 — a missense change in RABEP2.

What ClinVar records

Classification Benign/Likely benign for Immunodeficiency, common variable, 3; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 11 submitters), last evaluated 2026-02-04. ClinVar record 318803 NM_001770.6(CD19):c.520C>G (p.Leu174Val)

What this is ClinVar's aggregate record for this position (as of its 2026-10-05 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Parkinson's disease or first degree relation to individual with Parkinson's disease compared to the general population.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Parkinson's disease or first degree relation to individual with Parkinson's disease.

G/G Published research associates this genotype with typical/baseline likelihood of Parkinson's disease or first degree relation to individual with Parkinson's disease — no copies of the reported risk allele.

Source

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A, Bras J, Young E

and 39 more — show all

23andMe Research Team · System Genomics of Parkinson's Disease Consortium · International Parkinson's Disease Genomics Consortium

The Lancet. Neurology · 2019 · PMID 31701892

Questions about rs2904880

What is rs2904880?

rs2904880 is a single position in the genome, in or near the CD19 gene. Published research associates it with parkinson's disease or first degree relation to individual with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2904880 linked to?

On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs2904880 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2904880 come from?

GWAS Catalog, Lancet Neurol 2019, PMID:31701892. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Parkinson's disease or first degree relation to individual with Parkinson's disease (rs2904880). MyGeneLog™. https://www.mygenelog.com/variants/rs2904880

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