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Plasma estrone conjugates levels in resected early stage estrogen-receptor positive breast cancer

SLCO1B1 · rs2900478

Where this position leads

Condition: Breast Cancer

Drugs: Statins, Ticagrelor

rs2900478 Condition: Breast Cancer Breast Cancer Condition Drug: Statins Statins Drug Drug: Ticagrelor Ticagrelor Drug rs2900478 rs2900478 SLCO1B1

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Plasma estrone conjugates levels in resected early stage estrogen-receptor positive breast cancer compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Plasma estrone conjugates levels in resected early stage estrogen-receptor positive breast cancer.
T/T Published research associates this genotype with typical/baseline likelihood of Plasma estrone conjugates levels in resected early stage estrogen-receptor positive breast cancer — no copies of the reported risk allele.
Source
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway
Dudenkov TM, Ingle JN, Buzdar AU, Robson ME, Kubo M, Ibrahim-Zada I, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Barman P, Goetz MP
and 7 more — show all
Northfelt DW, Moreno-Aspita A, Williard CV, Kalari KR, Nakamura Y, Wang L, Weinshilboum RM
Breast cancer research and treatment · 2017 · PMID 28429243

Questions about rs2900478

What is rs2900478?

rs2900478 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with plasma estrone conjugates levels in resected early stage estrogen-receptor positive breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2900478 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does rs2900478 affect how medicines work?

SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2900478 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2900478 come from?

GWAS Catalog, Breast Cancer Res Treat 2017, PMID:28429243. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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