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Atrial fibrillation

KCNN2 · rs2900084

Where this position leads

Condition: Atrial Fibrillation

rs2900084 Condition: Atrial Fibrillation Atrial Fibrillation Condition rs2900084 rs2900084 KCNN2

What the study found

Who was studied 1,782 Admix African and African American ancestry cases, 9,356 Admix African and African American ancestry controls, 11,350 East Asian ancestry cases, 137,515 East Asian ancestry controls, 166,322 European ancestry cases, 1,313,950 European ancestry controls, 1,774 Hispanic or Latin American cases, 7,665 Hispanic or Latin American controls, 218 South Asian ancestry cases, 413 South Asian ancestry controls.

The effect Each copy of the A allele carried 1.06 times the odds of Atrial fibrillation (95% confidence interval 1.05-1.07); p = 3 × 10−31.

How common The A allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 5, band 5q22.3 — in an intron of KCNN2.

What each result means

A/A Two copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/G No copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
Source

Questions about rs2900084

What is rs2900084?

rs2900084 is a single position in the genome, in or near the KCNN2 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2900084 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

Does having rs2900084 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2900084 come from?

GWAS Catalog, Nature genetics 2025, PMID:40050429. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (rs2900084). MyGeneLog™. https://www.mygenelog.com/variants/rs2900084

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